An F-box protein, FWD1, mediates ubiquitin- dependent proteolysis of β-catenin
نویسندگان
چکیده
1Department of Molecular and Cellular Biology and 4Laboratory of Embryonic and Genetic Engineering, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, 2CREST, Japan Science and Technology Corporation (JST), 4-1-8 Honcho, Kawaguchi, Saitama 332-0012 and 3First Department of Biochemistry, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-0037, Japan
منابع مشابه
A dominant-negative F-box deleted mutant of E3 ubiquitin ligase, β-TrCP1/FWD1, markedly reduces myeloma cell growth and survival in mice
Treatment of multiple myeloma with bortezomib can result in severe adverse effects, necessitating the development of targeted inhibitors of the proteasome. We show that stable expression of a dominant-negative F-box deleted (âF) mutant of the E3 ubiquitin ligase, SCFβ-TrCP/FWD1, in murine 5TGM1 myeloma cells dramatically attenuated their skeletal engraftment and survival when inoculated into ...
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stabilization and accumulation of hypophosphorylated β-catenin is a central component of the cadherin cell Arm/β-catenin (Peifer et al., 1994a,b), which is believed adhesion complex and plays an essential role in the to interact with downstream-acting transcription factors Wingless/Wnt signaling pathway. In the current model (Behrens et al., 1996; Huber et al., 1996b; Molenaar et al., of this p...
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تاریخ انتشار 2013